CARcinogen EXposure: CAREX

CAREX Canada: an enhanced model for assessing occupational carcinogen exposure

OBJECTIVES To estimate the numbers of workers exposed to known and suspected occupational carcinogens in Canada, building on the methods of CARcinogen EXposure (CAREX) projects in the European Union (EU). METHODS CAREX Canada consists of estimates of the prevalence and level of exposure to occupational carcinogens. CAREX Canada includes occupational agents evaluated by the International Agenc...

Occupational carcinogen exposure in Canada.

My colleague Professor John Cherrie once said that we know more about the number of birds breeding in British meadows each year (see http://jncc.defra. gov.uk/pdf/BBSreport12_web.pdf) than the number of workers exposed to carcinogens in the workplace. It is clearly important to monitor bird populations, but I would consider it of at least equal importance to know what hazardous agents workers a...

Avoiding carcinogen exposure with intraperitoneal paclitaxel.

PURPOSE/OBJECTIVES Diethylhexylphthalate (DEHP) is a lipid-soluble plasticizer commonly used in the manufacture of polyvinyl chloride- (PVC-) based plastics. Previous studies have documented the leaching of DEHP from PVC-based containers and extension sets during the IV administration of paclitaxel. DESIGN Study of the leaching of DEHP from infusion bags and peritoneal dialysis solution trans...

Roll-your-own cigarettes and carcinogen exposure

Carcinogen exposure and gene promoter hypermethylation in bladder cancer.

Tobacco smoking, certain occupational exposures, and exposure to inorganic arsenic in drinking water have been associated with the occurrence of bladder cancer. However, in these tumors the exposure-associated pattern of somatic alterations in genes in the causal pathway for disease has been poorly characterized. In particular, the mechanism by which arsenic induces bladder cancer and the effec...